Efficacy of phentolamine mesylate in reducing the duration of various local anesthetics
Gago-Garcia Alejandro, Barrilero-Martin Cayetana, Alobera-Gracia Miguel Angel, del Canto-Pingarron Mariano, Seco-Calvo Jesus,
소속 상세정보
( Gago-Garcia Alejandro ) - University of Leon
( Barrilero-Martin Cayetana ) - University of Leon
( Alobera-Gracia Miguel Angel ) - University of Leon
( del Canto-Pingarron Mariano ) - University of Leon
( Seco-Calvo Jesus ) - University of Leon Institute of Biomedicine
Abstract
Background: To evaluate changes in the effectiveness of phentolamine mesylate in combination with different local anesthetics (LAs) and vasoconstrictors. A prospective randomized double-blind study was conducted with 90 patients divided into three groups, with each group being administered one of three different LAs: lidocaine 2% 1/80,000, articaine 4% 1/200,000, and bupivacaine 0.5% 1/200,000.
Methods: We compared treatments administered to the mandible involving a LA blockade of the inferior alveolar nerve. Results were assessed by evaluating reduction in total duration of anesthesia, self-reported patient comfort using the visual analog pain scale, incidence rates of the most common adverse effects, overall patient satisfaction, and patient feedback.
Results: The differences among the three groups were highly significant (P < 0.001); time under anesthesia was especially reduced for both the lip and tongue with bupivacaine. The following adverse effects were reported: pain at the site of the anesthetic injection (11.1%), headaches (6.7%), tachycardia (1.1%), and heavy bleeding after treatment (3.3%). The patients' feedback and satisfaction ratings were 100% and 98.9%, respectively.
Conclusions: Efficient reversal of LAs is useful in dentistry as it allows patients to return to normal life more readily and avoid common self-injuries sometimes caused by anesthesia. Phentolamine mesylate reduced the duration of anesthesia in the three studied groups, with the highest reduction reported in the bupivacaine group (from 460 min to 230 min for the lip and 270 min for the tongue [P < 0.001]).
키워드
Articaine; Bupivacaine; Epinephrine; Lidocaine; Local Anesthesia; Phentolamine Mesylate
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